Lewis acid/NHC dual catalysis for regioselective vicinal decarboxylative carbonylation–acylation of alkenes
Abstract
a concerted SET between the enolate form of the Breslow intermediate and a Lewis acid-activated NHPI ester, followed by CO trapping and regioselective recombination of multiple radical intermediates to install two distinct carbonyl groups. This strategy constitutes a new platform for C1 exchange and enables efficient CO incorporation even with sterically demanding or conformationally rigid alkyl radicals.
Fields of Study & Subjects
Catalytic C–H Functionalization Methods
N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
Carbon dioxide utilization in catalysis
Publication details
- Journal / source
- Chemical Science
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 17
- Issue
- 16
- Pages
- 8054–8060
- Publication date
- 1 January 2026
- Language
- EN