Conversion of trifluoromethyls into esters along with polyether upcycling via cation-transfer-catalyzed C–O/C–F metathesis
Abstract
)-O bonds. This approach facilitates the defluoroalkoxylation of trifluoromethyl-substituted substrates and polyfluoroalkanes when combined with ethers or polyethers, thus building a bridge to convert trifluoromethyl groups into ester/ketone groups, along with polyether upcycling. We provide crystallographic evidence that clearly confirms that this reaction involves the formation of silyloxonium ions and Meerwein-type salt intermediates, followed by cationic ligand transformations.
Fields of Study & Subjects
Fluorine in Organic Chemistry
Synthetic Organic Chemistry Methods
Cyclopropane Reaction Mechanisms
Publication details
- Journal / source
- Chemical Science
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 17
- Issue
- 20
- Pages
- 9952–9959
- Publication date
- 1 January 2026
- Language
- EN