Influence of block microstructure on the interaction of styrene-maleic acid copolymer aggregates and lipid nanodiscs

Soft Matter 2026 Open access

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Authors: George M. Neville, Aya Ayman Nasser, James J Doutch, Stephen M. King, Pedro Estrela, Paul R. Whitley, Gareth James Price, Karen J. Edler
DOI: 10.1039/d5sm01014d
Cited by: 0
References: 69

Abstract

membranes, the impact of both block distribution and end group chemistry on copolymer-membrane interactions was investigated. It was found that mismatched hydrophilic and hydrophobic end groups on the styrene block and alternating block, respectively, impeded membrane disruption and subsequent solubilisation. This highlights not only how the amphiphilic balance of these blocks is important for efficient nanodisc formation, but also how end groups influence these and may be optimised towards extraction of more challenging MPs. The work contributes to a better understanding of SMA behaviour and offers insight into how these nanomaterials may be better designed and tailored for specific applications.

Fields of Study & Subjects

Lipid Membrane Structure and Behavior Block Copolymer Self-Assembly Advanced Polymer Synthesis and Characterization

Publication details

Journal / source
Soft Matter
Volume
22
Issue
4
Pages
994–1007
Publication date
1 January 2026
Language
EN