Retina microrheology via oscillatory atomic force microscopy
Abstract
) = 0.263), suggesting changes in the extracellular matrix and highlighting how retinopathy may alter matrix properties. Finally, to assess the feasibility of using microrheology AFM on banked tissues biospecimens, we examined how tissue fixation affects the measurements. We found that formaldehyde fixation increased stiffness and elasticity, with OIR tissues consistently stiffer than WT tissues in both fixed and unfixed tissues, enabling valid cross-treatment comparisons. Our findings establish the benefits of microrheology in capturing tissue mechanical behavior, which is important for studying disease impact on tissue mechanics. This approach offers new insights into tissue viscoelasticity with implications for studying the dynamics of tissue mechanics in diseases and regeneration.
Fields of Study & Subjects
Cellular Mechanics and Interactions
Force Microscopy Techniques and Applications
Retinal and Macular Surgery
Publication details
- Journal / source
- Soft Matter
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 22
- Issue
- 14
- Pages
- 2629–2637
- Publication date
- 1 January 2026
- Language
- EN