Drug & virus transport across biological barriers: interactions, diffusion, partitioning, permeability, and selectivity
Abstract
-scale attractive interactions, that are either specific or non-specific, can yield optimal delivery of larger particles, to increase the mass flux across mucus barriers by an order of magnitude, and enable delivery of macromolecular cargo, due to enhanced partitioning. Our model indicates drug particle design rules to achieve transport rates comparable to or exceeding what is possible by viruses with highly evolved chemical and physical characteristics.
Fields of Study & Subjects
Advanced Drug Delivery Systems
Graphene and Nanomaterials Applications
Nanoparticle-Based Drug Delivery
Publication details
- Journal / source
- Soft Matter
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 22
- Issue
- 7
- Pages
- 1630–1642
- Publication date
- 1 January 2026
- Language
- EN