Multi-step mechanisms of early phospholipid hydrolysis and mineralisation unveiled through combined quantum chemical calculations and experimental analysis

Journal of Materials Chemistry B 2026 Open access

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Authors: Keisuke Shibata, Takahumi Shiotani, Y. Chen, Reina Kurihara, Katsunori Yamaguchi, Emilio Satoshi Hara, Nílson Kunioshi
DOI: 10.1039/d5tb01744k
Cited by: 0
References: 28

Abstract

Phospholipids play key roles in bone formation, with phosphatidylserine (PS) reportedly inducing more rapid mineralisation than phosphatidylcholine (PC); however, the underlying mechanisms remains unclear.

Fields of Study & Subjects

Alkaline Phosphatase Research Studies Calcium Carbonate Crystallization and Inhibition Bone Tissue Engineering Materials

Publication details

Journal / source
Journal of Materials Chemistry B
Volume
14
Issue
5
Pages
1671–1681
Publication date
1 January 2026
Language
EN