Zinc ions and zinc-embedded carbon quantum dots as competitive inhibitors of fumarase: preferential inhibition of the reverse reaction
Abstract
interacts with Glu340, a residue previously shown to be involved in binding fumarase inhibitors. These findings establish Zn-CQDs as a novel class of water-soluble fumarase inhibitors, distinguished by their facile synthesis, tunable solubility, and selective inhibition profile. This work highlights the potential of zinc-based nanomaterials in enzyme regulation, offering a powerful alternative to existing inhibitors and developing targeted redox-sensitive therapeutic strategies.
Fields of Study & Subjects
Carbon and Quantum Dots Applications
Advanced Nanomaterials in Catalysis
Electrochemical sensors and biosensors
Publication details
- Journal / source
- Journal of Materials Chemistry B
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 14
- Issue
- 7
- Pages
- 2359–2372
- Publication date
- 1 January 2026
- Language
- EN