A macrocyclic gadolinium contrast agent bearing an assembly-dissociable feature with albumin for enhanced magnetic resonance imaging and in vivo profiles

Journal of Materials Chemistry B 2026

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Authors: Yimin Gong, Yichen Yao, Zhuoying Ruan, Nan Mei, Dan Luo, Xiaofeng Liu, Yongtai Yang, Yu Jia, Yannan Yang, Bo Yin, Yaming Zhou, Yun Ling
DOI: 10.1039/d5tb02169c
Cited by: 0
References: 47

Abstract

A novel macrocyclic GBCA, namely Gd-IN-DO3A, was designed, which exhibits an assembly-dissociable feature with HSA at Sudlow site II via moderate non-covalent interactions. The HSA-adducts ensure enhanced T 1 -weighted MRI and favorable in vivo profiles.

Fields of Study & Subjects

Lanthanide and Transition Metal Complexes Nanoparticle-Based Drug Delivery Nanoplatforms for cancer theranostics

Publication details

Journal / source
Journal of Materials Chemistry B
Volume
14
Issue
8
Pages
2495–2505
Publication date
1 January 2026
Language
EN