Ratiometric near-infrared fluorescence probes for quantitative monitoring of mitochondrial pH dynamics in Drosophila melanogaster and HeLa cells during metformin treatment
Abstract
larvae. Significantly, treatment with metformin was shown to alter mitochondrial pH levels, demonstrating the probes' utility in studying drug effects. Collectively, these findings establish AH+ and BH+ as powerful tools for probing mitochondrial function and cellular stress responses, offering new opportunities to explore fundamental mechanisms underlying health and disease.
Fields of Study & Subjects
Molecular Sensors and Ion Detection
Analytical Chemistry and Sensors
Cancer
Hypoxia
and Metabolism
Publication details
- Journal / source
- Journal of Materials Chemistry B
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 14
- Issue
- 7
- Pages
- 2304–2323
- Publication date
- 1 January 2026
- Language
- EN