Injectable hydrogel-based localized delivery of IDO-galectin-3 mitigates neuroinflammation and promotes neuronal sparing after spinal cord contusion in rats

Journal of Materials Chemistry B 2026 Open access

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Authors: Gopal Surajbhan Agarwal, Allison Campbell, Arun Wanchoo, Daniel Plant, Izabela Zmirska, Jacob Fuhr, Prodip Bose, Gregory A. Hudalla, Benjamin George Keselowsky, Christine E. Schmidt
DOI: 10.1039/d5tb02228b
Cited by: 1
References: 93

Abstract

magnetic resonance imaging (MRI) revealed that this combination treatment resulted in increased neuronal sparing of the corticospinal tract compared to either IDO-Gal3 or iPN alone. While no statistical difference was observed in Basso, Beattie, and Bresnahan or horizontal ladder locomotor assessments, rats treated with iPN + IDO-Gal3 exhibited more weight-supported steps, coordinated movement, and plantar paw accuracy. Collectively, these findings suggest that the localized delivery of IDO-Gal3 through a pro-regenerative hydrogel delivery vehicle is a promising strategy to attenuate neuroinflammation and support axonal preservation following SCI.

Fields of Study & Subjects

Galectins and Cancer Biology Nerve injury and regeneration Spinal Cord Injury Research

Publication details

Journal / source
Journal of Materials Chemistry B
Publisher
Royal Society of Chemistry (RSC)
Volume
14
Issue
11
Pages
3464–3479
Publication date
1 January 2026
Language
EN