Design and synthesis of enediyne chimeras for targeted degradation of PD-L1
Abstract
) of 44 nM, independent of both proteasomal and lysosomal activity. Furthermore, the targeted PD-L1 degradation reversed tumor immune evasion and enhanced cancer cell killing by peripheral blood mononuclear cells. This study establishes the PROTEC platform as a robust and modular strategy for degrading membrane-associated and extracellular disease-relevant proteins.
Fields of Study & Subjects
Cyclization and Aryne Chemistry
Protein Degradation and Inhibitors
Click Chemistry and Applications
Publication details
- Journal / source
- Journal of Materials Chemistry B
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 14
- Issue
- 10
- Pages
- 3202–3209
- Publication date
- 1 January 2026
- Language
- EN