Polycationic silk fibroin chelating nano-hydroxyapatite promotes angiogenesis for burn wound healing
Abstract
. Furthermore, the dressing demonstrated a remarkable pro-angiogenic capacity, as validated by the tube formation assays. In a rat model with deep partial-thickness burns, treatment with the CSF-nHA dressing resulted in the formation of highly vascularized neo-tissue. This enhanced vascularization facilitated superior collagen deposition, tissue regeneration, and accelerated wound closure. This study combined inorganic nHA nanoparticles with bioactive CSF macromolecules, offering a promising strategy for the management of burn wounds by promoting rapid revascularization.
Fields of Study & Subjects
Silk-based biomaterials and applications
Wound Healing and Treatments
Corneal Surgery and Treatments
Publication details
- Journal / source
- Journal of Materials Chemistry B
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 14
- Issue
- 5
- Pages
- 1574–1585
- Publication date
- 1 January 2026
- Language
- EN