Application of the novel polysaccharide “colanic acid (CA)” in submucosal injection and wound repair for endoscopic submucosal dissection
Abstract
ESD model in pigs, it was verified that CA has better lifting performance than HA, and it could shorten the cutting time and reduce the number of injections during ESD. Furthermore, transcriptomic results suggest that CA promotes the enrichment of pathways related to wound healing compared with HA. This finding was further validated in a gastric ulcer model in rats, and the results indicate that CA has a better ulcer repair effect than HA. In conclusion, by integrating excellent physicochemical properties and multi-dimensional biological activities, the CA polysaccharide achieves synergistic optimization of procedural convenience, operational safety, and efficient wound healing across pre-, intra-, and post-operative phases of ESD, demonstrating promising clinical application prospects.
Fields of Study & Subjects
Gastric Cancer Management and Outcomes
Esophageal Cancer Research and Treatment
Polysaccharides Composition and Applications
Publication details
- Journal / source
- Journal of Materials Chemistry B
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 14
- Issue
- 9
- Pages
- 2877–2893
- Publication date
- 1 January 2026
- Language
- EN