Amplifying the “ in situ vaccination” of BET inhibition via autophagy blockade: mechanisms and local delivery in OSCC
Abstract
T-cell responses. To enable localized and efficient delivery, we engineered self-assembled JQ1/CQ nanoparticles stabilized through π-π stacking and integrated them into dissolvable cryomicroneedles. This minimally invasive platform ensures sustained drug release, improves tumor accumulation, and minimizes systemic exposure. Our study not only elucidates a druggable autophagy-ERS-ICD axis but also provides a versatile transdermal delivery strategy with potential applicability to a range of solid tumors.
Fields of Study & Subjects
Protein Degradation and Inhibitors
Autophagy in Disease and Therapy
Immunotherapy and Immune Responses
Publication details
- Journal / source
- Journal of Materials Chemistry B
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 14
- Issue
- 8
- Pages
- 2518–2529
- Publication date
- 1 January 2026
- Language
- EN