The effect of ionizable lipids on the cellular uptake of lipid bilayer coated mesoporous silica nanoparticles in the liver
Abstract
, a flow cytometry analysis revealed minimal uptake of I-silicasomes by hepatic parenchymal cells, with no statistical difference from that of C-silicasomes. In contrast, I-liposomes exhibited a higher delivery efficiency compared with C-liposomes. SDS-PAGE analysis indicated that all particles except I-liposomes exhibited very weak ApoE adsorption. Subsequent nano LC-MS/MS analysis further confirmed the low ApoE adsorption affinity of both C-silicasomes and I-silicasomes after serum incubation, which may account for their limited hepatocyte targeting. Collectively, these findings provide valuable information for guiding the future design and optimization strategies in liver-targeted nanocarrier development.
Fields of Study & Subjects
Lipid Membrane Structure and Behavior
Nanoparticle-Based Drug Delivery
Liver physiology and pathology
Publication details
- Journal / source
- Journal of Materials Chemistry B
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 14
- Issue
- 6
- Pages
- 1869–1881
- Publication date
- 1 January 2026
- Language
- EN