Synergistic mechanochemical regulation in PNIPAM/tannic acid hydrogels for enhanced diabetic wound healing
Abstract
its phenolic hydroxyl groups, effectively scavenged ROS, mitigating oxidative stress. The thermoresponsive PNIPAM network exhibited temperature-dependent shrinkage, mimicking the contractile behavior of myofibroblasts to actively promote wound edge closure. Experimental results demonstrated that the hydrogel possessed excellent biocompatibility, antioxidant capacity, and dynamic mechanical adaptability. The synergistic combination of physical contraction and chemical regulation accelerated diabetic wound healing. This strategy may provide a novel approach for chronic wound therapy by integrating mechanical stimulation with biochemical modulation.
Fields of Study & Subjects
Wound Healing and Treatments
Hydrogels: synthesis
properties
applications
Polymer Surface Interaction Studies
Publication details
- Journal / source
- Journal of Materials Chemistry B
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 14
- Issue
- 14
- Pages
- 4295–4310
- Publication date
- 1 January 2026
- Language
- EN