A molecular engineering platform for enhanced Stokes shift NIR-II fluorophores enabling high-fidelity 1400 nm in vivo imaging
Abstract
benzannulation and terminal donor engineering. This approach facilely yields a series of novel asymmetric xanthene dyes (NIR-820, NIR-842, and NIR-864) exhibiting tunable deep-NIR emission, enhanced Stokes shifts (∼54 nm), and remarkable photo/chemo-stability. The representative NIR-842 nanoparticles enabled high-contrast visualization of vasculature networks. Impressively, leveraging its extended emission tail beyond 1400 nm, high-fidelity real-time angiography with an outstanding signal-to-background ratio was achieved under 1400 nm long-pass filtration. This work not only presents a robust fluorophore for high-quality bioimaging, but also establishes a versatile molecular platform for the future development of high-performance NIR-II probes.
Fields of Study & Subjects
Nanoplatforms for cancer theranostics
Optical Imaging and Spectroscopy Techniques
Lanthanide and Transition Metal Complexes
Publication details
- Journal / source
- Journal of Materials Chemistry B
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 14
- Issue
- 12
- Pages
- 3840–3847
- Publication date
- 1 January 2026
- Language
- EN