Conjugating M13 bacteriophage targeting folate receptor alpha with multiple photosensitizers: a flexible phototheranostic platform against ovarian cancer

Journal of Materials Chemistry B 2026 Open access

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Authors: Alena Kaltenbrunner, Andrea Martino, Michela Nigro, Andrea Carboni, Andrea Carboni, Nicolò Mercorelli, Manuele Di Sante, Chiara Di Donato, Annapaola Petrosino, Simona Corra, Monica De Luise, Giuseppe Gasparre
+4 more Matteo Calvaresi, Alberto Danielli, Paolo Emidio Costantini, Matteo Di Giosia
DOI: 10.1039/d5tb02844b
Cited by: 1
References: 67

Abstract

-Ce6-RB conjugates exhibit potent photodynamic activity under both red and green light irradiation, highlighting the potential of refactored M13 phages as flexible nanocarriers for precision phototherapy. This work presents a customizable and translationally relevant nanoplatform for image-guided treatment of chemoresistant ovarian cancer and other FRα-positive malignancies.

Fields of Study & Subjects

Cancer Research and Treatments Nanoplatforms for cancer theranostics Photodynamic Therapy Research Studies

Publication details

Journal / source
Journal of Materials Chemistry B
Publisher
Royal Society of Chemistry (RSC)
Volume
14
Issue
23
Pages
7164–7178
Publication date
1 January 2026
Language
EN