Water-soluble acylhydrazone macrocycles as potent reversal agents for cisatracurium-induced neuromuscular blockade

Journal of Materials Chemistry B 2026 Open access

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Authors: Yongfei Yin, Yangyang Ge, Qian Li, Yi Chen, Siyuan Zhou, He Deng, Shigui Chen, Yun Lin, Lu Wang
DOI: 10.1039/d5tb02867a
Cited by: 0
References: 44

Abstract

studies in cisatracurium-anesthetized mice demonstrated that the macrocycle effectively reverses cisatracurium-induced neuromuscular blockade. This work provides a new strategy for developing water-soluble acylhydrazone macrocycles as potential supramolecular reversal agents for neuromuscular blockers.

Fields of Study & Subjects

Anesthesia and Sedative Agents Supramolecular Chemistry and Complexes Nicotinic Acetylcholine Receptors Study

Publication details

Journal / source
Journal of Materials Chemistry B
Volume
14
Issue
14
Pages
4311–4318
Publication date
1 January 2026
Language
EN