Scalable one-step synthesis of gelatin–dithiolane for neural tissue engineering
Abstract
physiochemical crosslinking allowed the fabrication of GelDT hydrogels at a remarkably low gelatin concentration (1.5% w/v) while ensuring fast gelation. The GelDT hydrogel supported the high viability and metabolic activity of encapsulated human iPSC-derived neural progenitor cell (NPC) spheroids. The GelDT hydrogel maintained NPC stemness (SOX2+, Ki-67+) and facilitated successful neuronal differentiation (MAP2+) in 3D culture. This work establishes a scalable, cytocompatible platform for producing dynamic protein-based hydrogels for regenerative medicine.
Fields of Study & Subjects
Hydrogels: synthesis
properties
applications
Electrospun Nanofibers in Biomedical Applications
Tissue Engineering and Regenerative Medicine
Publication details
- Journal / source
- Journal of Materials Chemistry B
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 14
- Issue
- 12
- Pages
- 3848–3859
- Publication date
- 1 January 2026
- Language
- EN