Advances in fluorescence-based point-of-care diagnostics: probes, nanostructures and integrated systems

Journal of Materials Chemistry C 2026 Open access

Read full text
Authors: Manuela Cedrún-Morales, Enrica Soprano, Giulia Vanoni, Anil Chandra, Helena Iuele, Francesco Colella, Stefania Forciniti, Valentina Onesto, Giuliana Grasso, Giuseppe Gigli, Loretta L. del Mercato
DOI: 10.1039/d5tc04199f
Cited by: 9
References: 247

Abstract

Fluorescence-based point-of-care (POC) technologies are rapidly evolving through advances in materials chemistry. This review provides a comprehensive overview of fluorescent molecular probes, proteins, hybrid nanostructures, metal-organic frameworks, silica platforms, carbon dots, and upconverting nanoparticles engineered for portable diagnostics. We highlight fundamental photophysical mechanisms, design strategies for improving brightness, stability, and multiplexing, and the integration of fluorescent materials with microfluidics, wearable interfaces, and smartphone readouts. Current limitations, translational challenges, and emerging trends, including AI-enabled data analysis and next-generation NIR and AIE fluorophores, are discussed. Together, these insights outline how material innovation is driving the next generation of high-performance POC sensing systems.

Fields of Study & Subjects

Carbon and Quantum Dots Applications Luminescence and Fluorescent Materials Molecular Sensors and Ion Detection

Publication details

Journal / source
Journal of Materials Chemistry C
Publisher
Royal Society of Chemistry (RSC)
Volume
14
Issue
14
Pages
5607–5628
Publication date
1 January 2026
Language
EN