Chronic PFOA and PFOS exposure triggers cellular oxidative stress and alters lipid levels as revealed through multi-omics analysis

Environmental Science Advances 2026 Open access

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Authors: Jenise Z. Paddayuman, Judith Cristobal, L. Landau, Ashleigh L. Gagnon, Omer Gokcumen, Diana S Aga, G. Ekin Atilla‐Gokcumen
DOI: 10.1039/d5va00353a
Cited by: 3
References: 61

Abstract

Prolonged, low-dose exposure to PFOA and PFOS results in cumulative disruptions in lipid metabolism and induces sustained cellular stress responses in human epithelial cells.

Fields of Study & Subjects

Per- and polyfluoroalkyl substances research Effects and risks of endocrine disrupting chemicals Fluorine in Organic Chemistry

Publication details

Journal / source
Environmental Science Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
5
Issue
4
Pages
1081–1094
Publication date
1 January 2026
Language
EN