Increasing PFAS concentrations in human serum correlate with elevated blood lipid levels

Environmental Science Advances 2026 Open access

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Authors: Ashlee T. Falls, Anna K. Boatman, Jack P. Ryan, Amie M Solosky, James N. Dodds, Jessie R. Chappel, Allison Nicole Fry, Kaylie I. Kirkwood‐Donelson, Heather M. Stapleton, Erin Baker
DOI: 10.1039/d5va00483g
Cited by: 5
References: 77

Abstract

. Triglycerides and phosphatidylethanolamines specifically represented 62.5% of these 24 lipids, suggesting alteration of cellular membrane structures and energy storage. A statistical assessment on the female-only samples from the drinking water cohort was also performed to reduce bias due to sex, age and occupational covariates and further validated these trends. This study therefore illustrates increased serum PFAS concentrations correlate with elevated lipid species and molecular pathway alterations in highly exposed individuals.

Fields of Study & Subjects

Per- and polyfluoroalkyl substances research Fluorine in Organic Chemistry Toxic Organic Pollutants Impact

Publication details

Journal / source
Environmental Science Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
5
Issue
3
Pages
885–899
Publication date
1 January 2026
Language
EN