Separating O -desmethylvenlafaxine and tramadol enantiomers using two-dimensional chiral LC × DMS mass spectrometry

The Analyst 2026 Open access

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Authors: A. Dawson McLachlan, Rashne Vakharia, Emir Nazdrajić, Diana M. Cárdenas-Soracá, Leslie M. Bragg, Mark Roy Servos, W. Scott Hopkins
DOI: 10.1039/d6an00119j
Cited by: 0
References: 50

Abstract

A novel hybrid workflow including chiral LC and differential mobility spectrometry was used to separate and quantify the enantiomers of a set of co-eluting isomers.

Fields of Study & Subjects

Analytical Chemistry and Chromatography Mass Spectrometry Techniques and Applications Forensic Toxicology and Drug Analysis

Publication details

Journal / source
The Analyst
Volume
151
Issue
10
Pages
2781–2790
Publication date
1 January 2026
Language
EN