Rational design of environment-sensitive fluorescent probes for butyrylcholinesterase and their application in biological imaging

Analytical Methods 2026

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Authors: Lulian Shao, Feng Wang, Yu Wang, Jiahao Du, Wenting Cao, QingWen ZHANG, Fenqin Zhao, Junfeng Wang, Wenhui Fan, Yuemin Zhou, Bingxin Wang, Xiaobin Pang
+1 more Lin Yan
DOI: 10.1039/d6ay00158k
Cited by: 1
References: 33

Abstract

of tacrine (7.83 nM), a standard BChE inhibitor, demonstrating its reliability in evaluating BChE inhibition. Due to its high sensitivity, rapid response, and superior selectivity, ESP4 enabled real-time imaging of BChE in biological systems such as cells, zebrafish, and AD mouse models. Collectively, these findings highlighted ESP4 as a valuable tool for BChE detection, contributing to a deeper understanding of the physiological role of BChE in health and disease.

Fields of Study & Subjects

Cholinesterase and Neurodegenerative Diseases Carbon and Quantum Dots Applications Electrochemical sensors and biosensors

Publication details

Journal / source
Analytical Methods
Publisher
Royal Society of Chemistry (RSC)
Volume
18
Issue
15
Pages
3216–3223
Publication date
1 January 2026
Language
EN