Copper sulfide nanoparticles coated with Fe-EGCG networks for targeted MR imaging and chemo/photothermal/chemodynamic synergetic therapy of tumors
Abstract
. Notably, EGCG and NIR laser irradiation could enhance Fe-mediated Fenton reaction efficiency, increasing hydroxyl radical (˙OH) production and potentiating chemodynamic therapy efficacy. Through effectively generating reactive oxygen species (ROS), consuming glutathione (GSH), accumulating lipid peroxidation (LPO), and promoting cancer cell apoptosis under laser irradiation, the FA-CuS PENs@Fe-EGCG nanocomposites could exert superior tumor suppression efficacy in the 4T1 xenograft mice model by targeted chemo/photothermal/chemodynamic synergetic therapy. This work presents a succinct design of advanced nanocomposites incorporating CuS NPs and MPNs, offering a promising strategy for tumor theranostics.
Fields of Study & Subjects
Nanoplatforms for cancer theranostics
Gold and Silver Nanoparticles Synthesis and Applications
Nanocluster Synthesis and Applications
Publication details
- Journal / source
- Biomaterials Science
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 14
- Issue
- 9
- Pages
- 2384–2402
- Publication date
- 1 January 2026
- Language
- EN