An ROS-responsive antioxidant hydrogel with immunomodulatory activity for promoting diabetic wound healing

Biomaterials Science 2026

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Authors: Yurao Liu, Qianqian Yang, Ling Zhang, Qiyue Lu, Yuhang Li, Haisong Zhang, Chunfang Zhang, Pingli Wu
DOI: 10.1039/d6bm00018e
Cited by: 5
References: 41

Abstract

evaluation results show that this hydrogel can effectively alleviate oxidative stress, accelerating cell migration, proliferation, and angiogenesis. Transcriptome sequencing analysis further revealed that its pro-healing effects are mechanistically associated with key signaling pathways, especially PI3K-AKT and PPAR signaling pathways, to facilitate cell proliferation and suppress inflammation. Overall, the hydrogel provides a straightforward but effective platform for chronic diabetic wound healing.

Fields of Study & Subjects

Wound Healing and Treatments Hydrogels: synthesis properties applications Corneal Surgery and Treatments

Publication details

Journal / source
Biomaterials Science
Publisher
Royal Society of Chemistry (RSC)
Volume
14
Issue
5
Pages
1292–1308
Publication date
1 January 2026
Language
EN