A precision therapy paradigm for noise-induced hearing loss: integrating transcriptome-guided drug repurposing with in situ hydrogel delivery

Biomaterials Science 2026

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Authors: Qinming Cai, Mengwen Shi, Jinlin Chen, Chenyang Kong, Xiaoying Wang, Ye Yuan, Junna Lu, Diwei Zheng, Yu Sun
DOI: 10.1039/d6bm00030d
Cited by: 2
References: 53

Abstract

noise). Collectively, our study establishes a closed-loop paradigm combining computational prediction with rational biomaterial design, providing a potent and safe non-steroidal auditory protection strategy for addressing cochlear synaptopathy.

Fields of Study & Subjects

Hearing Cochlea Tinnitus Genetics Vestibular and auditory disorders Hearing Loss and Rehabilitation

Publication details

Journal / source
Biomaterials Science
Publisher
Royal Society of Chemistry (RSC)
Volume
14
Issue
7
Pages
1723–1737
Publication date
1 January 2026
Language
EN