Amphiphilic guanidine-based lipids enhance mRNA delivery and immune activation

Biomaterials Science 2026

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Authors: Qi Wei, Ruoshui Li, Jiaqi Fan, Mengyuan Xu, Pengcheng Yuan, Jiwei Liu, Qian Wang, Youqing Shen, Nigel K.H. Slater, Jianbin Tang
DOI: 10.1039/d6bm00068a
Cited by: 0
References: 36

Abstract

. Furthermore, GL9 promoted dendritic cell maturation, highlighting its potential as an adjuvant for mRNA vaccines. Thus, GLs, which enhance both transfection and immune activation, were incorporated into five-component LNPs to establish a promising platform for mRNA vaccines and therapeutics, offering an innovative strategy to optimize LNP-mediated mRNA delivery.

Fields of Study & Subjects

RNA Interference and Gene Delivery Immunotherapy and Immune Responses Nanoparticle-Based Drug Delivery

Publication details

Journal / source
Biomaterials Science
Volume
14
Issue
6
Pages
1518–1529
Publication date
1 January 2026
Language
EN