Colon microenvironment restorative nano-armored probiotics–rosmarinic acid bioconjugation for synergistic alleviation of inflammatory bowel disease

Biomaterials Science 2026

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Authors: Pengyu Chen, Pandi Peng, Junru Wang, Xi Zhang, Yuxin Guo, Hao Yan, Boyi Wang, Kaiyu Zhang, Chunyang Liu, Tao Feng, Peng Li
DOI: 10.1039/d6bm00320f
Cited by: 1
References: 47

Abstract

) that accumulated on the probiotic surface facilitated the formation of a pH-responsive enteric coating. This coating, composed of hydroxypropyl methylcellulose acetate succinate (HPMCAS) mixed with sodium alginate (SA), acted as a protective nano-armor on the surface, yielding EcN-RA@AS/SA. This nano-armor protected the probiotics during gastric transit, ensuring their safe delivery to the intestine. In a mouse model of IBD, EcN-RA@AS/SA demonstrated efficacy in restoring the colon microenvironment by alleviating symptoms through downregulating the expression of proinflammatory cytokines, repairing the intestinal barrier, and regulating the gut flora.

Fields of Study & Subjects

Probiotics and Fermented Foods Inflammatory Bowel Disease Biochemical and Structural Characterization

Publication details

Journal / source
Biomaterials Science
Publisher
Royal Society of Chemistry (RSC)
Volume
14
Issue
10
Pages
2676–2687
Publication date
1 January 2026
Language
EN