Simvastatin attenuates endothelial dysfunction in a coronary artery-on-a-chip
Abstract
) regions. Importantly, for the first time, simvastatin was found to decouple ICAM-1 expression from shear. Consequently, under dysfunctional conditions, human immune cells adhered across the chip, with spatial mapping revealing preferential adhesion at the bifurcation, which was substantially reduced by pre-treatment with simvastatin. This coronary artery-on-a-chip establishes a system to spatially map functional changes in endothelial cell behaviour in response to differential shear, geometry and drug treatment, enabling future studies into plaque initiation events and treatment targets.
Fields of Study & Subjects
3D Printing in Biomedical Research
Coronary Interventions and Diagnostics
Cellular Mechanics and Interactions
Publication details
- Journal / source
- Biomaterials Science
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 14
- Issue
- 11
- Pages
- 2880–2893
- Publication date
- 1 January 2026
- Language
- EN