Introducing azobenzenes as solid phase peptide synthesis linkers

RSC Chemical Biology 2026 Open access

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Authors: Connor B. Śmieja, Lizun Xin, Tianhui Tang, Ryan Tan, Martin Lee, Alison N. Hulme
DOI: 10.1039/d6cb00028b
Cited by: 1
References: 32

Abstract

The C̲o̲umarin-L̲oaded A̲z̲obenzene (COLAZ) linker for SPPS produces peptides with an integrated fluorescent label. Upon its biocompatible cleavage with dithionite or glutathione, the latent fluorophore is revealed enabling live-cell peptide imaging.

Fields of Study & Subjects

Chemical Synthesis and Analysis Supramolecular Self-Assembly in Materials Click Chemistry and Applications

Publication details

Journal / source
RSC Chemical Biology
Publisher
Royal Society of Chemistry (RSC)
Volume
7
Issue
8
Pages
1553–1558
Publication date
1 January 2026
Language
EN