Synthesis of thermostable artificial nicotinamide cofactors: carba-NAD + and carba-NADP +

RSC Chemical Biology 2026 Open access

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Authors: Zinnia Dsouza, Jan‐Simon Jeshua Friedrichs, Manuel Döring, Nicolás Rincón Téllez, Luca Schmermund, Volker Sieber
DOI: 10.1039/d6cb00036c
Cited by: 1
References: 34

Abstract

Carbocyclic nicotinamide cofactors are synthesized via chemical and enzymatic routes, with strategies compared to improve access to costly biomimetics. These artificial cofactors exhibit high thermostability and broad oxidoreductase compatibility.

Fields of Study & Subjects

Enzyme Catalysis and Immobilization Cyclopropane Reaction Mechanisms Covalent Organic Framework Applications

Publication details

Journal / source
RSC Chemical Biology
Publisher
Royal Society of Chemistry (RSC)
Volume
7
Issue
7
Pages
1330–1340
Publication date
1 January 2026
Language
EN