Native carboxylate-assisted palladium/norbornene-mediated distal C–H functionalization of ferrocene

Chemical Communications 2026

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Authors: Princi Gupta, Brijesh Patel, Shivam Waske, Suchithra Madhavan, Manmohan Kapur
DOI: 10.1039/d6cc00066e
Cited by: 1
References: 56

Abstract

Herein, we disclose a ligand-enabled, auxiliary-free, native carboxylate-assisted Pd/norbornene (NBE)-mediated highly regioselective C(3)-arylation of commercially available ferrocene carboxylic acids. This unique approach utilizes the Catellani-type reaction for distal C-H activation in ferrocene, where the weak chelation-assisted palladacycle formed by proximal C-H activation relays the palladium to the distal C(3)-position mediated by NBE, resulting in C-C bond formation with aryl iodides.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Catalytic Cross-Coupling Reactions Cyclopropane Reaction Mechanisms

Publication details

Journal / source
Chemical Communications
Publisher
Royal Society of Chemistry (RSC)
Volume
62
Issue
23
Pages
6364–6367
Publication date
1 January 2026
Language
EN