Purple-light-induced synthesis of spiro-oxindole oximes from BCBs and TBN via strain release

Chemical Communications 2026

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Authors: Yibo Shi, Huanping Xie, En hui Fan, Weiguang Kong, XUE LI, Wenguang Li, Yongqi Yu, Heyun Sheng, Ting Li
DOI: 10.1039/d6cc00155f
Cited by: 1
References: 66

Abstract

-butyl nitrite (TBN). TBN serves a dual function in this transformation, acting as both a hydrogen atom transfer (HAT) reagent and the oxime group source. Its homolytic cleavage under visible light irradiation generates key radical species, enabling the subsequent steps. This strategy allows for the efficient and modular incorporation of diverse heterocycles onto the spiro-oxindole oxime scaffold under mild and operationally simple conditions. The successful downstream derivatizations further highlight the synthetic utility of this methodology.

Fields of Study & Subjects

Radical Photochemical Reactions Oxidative Organic Chemistry Reactions Catalytic C–H Functionalization Methods

Publication details

Journal / source
Chemical Communications
Publisher
Royal Society of Chemistry (RSC)
Volume
62
Issue
17
Pages
5073–5077
Publication date
1 January 2026
Language
EN