Metal-free, iodine-mediated multicomponent synthesis of bis-pyrazolo-pyridine derivatives

Chemical Communications 2026

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Authors: Karuppaiah Perumal, Markabandhu Shanthi, Vijayakumar Hemamalini, Bhaskaran Shankar, Subburethinam Ramesh
DOI: 10.1039/d6cc00245e
Cited by: 0
References: 21

Abstract

A one-pot, iodine-mediated, metal-free protocol has been developed for the synthesis of pyrazolo-fused pyridines from pyrazole amine, phenylglyoxal monohydrate, and phenylhydrazine hydrochloride. This method uses readily available substrates and offers a broad scope, and mechanistic studies reveal the role of iodine and the formation of 3 C-N and 2 C-C bonds.

Fields of Study & Subjects

Multicomponent Synthesis of Heterocycles Synthesis of heterocyclic compounds Synthesis and Reactivity of Heterocycles

Publication details

Journal / source
Chemical Communications
Volume
62
Issue
23
Pages
6356–6359
Publication date
1 January 2026
Language
EN