Nickel-catalyzed cross-electrophile-coupling of thioesters with alkyl bromides to form ketones under mechanochemical conditions

Chemical Communications 2026 Open access

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Authors: Ivo H. Lindenmaier, Robert C. Richter, Liesa Renz, Mattis T. Vochezer, Marius Schier, Pascal Faßnacht, Markus Ströbele, Ivana Fleischer
DOI: 10.1039/d6cc00297h
Cited by: 2
References: 47

Abstract

A solvent-minimized nickel-catalyzed synthesis of ketones, enabled by mechanochemistry, using thioesters as an acyl source is demonstrated. Mechanistic studies suggest a radical-chain-type mechanism.

Fields of Study & Subjects

Sulfur-Based Synthesis Techniques Vanadium and Halogenation Chemistry Catalytic Cross-Coupling Reactions

Publication details

Journal / source
Chemical Communications
Publisher
Royal Society of Chemistry (RSC)
Volume
62
Issue
18
Pages
5284–5288
Publication date
1 January 2026
Language
EN