Molecular engineering of ionic organic phototheranostic agents for NIR-II imaging-guided synergistic phototherapy

Chemical Communications 2026

View at publisher
Authors: Jianye Gong, Yue Zhang, Chen Lu, Guoyu Jiang, Quan Jin, Jianguo Wang
DOI: 10.1039/d6cc00306k
Cited by: 0
References: 45

Abstract

We develop ionic small-molecule phototheranostics by molecular engineering of positive charges and hydrophilicity/hydrophobicity balance. The optimized agent, 2PyI, achieves balanced amphiphilicity, enabling efficient NIR-II emission, reactive oxygen species generation, and photothermal conversion. It facilitates high-resolution NIR-II imaging-guided synergistic photodynamic/photothermal therapy.

Fields of Study & Subjects

Nanoplatforms for cancer theranostics Luminescence and Fluorescent Materials Photodynamic Therapy Research Studies

Publication details

Journal / source
Chemical Communications
Volume
62
Issue
19
Pages
5452–5456
Publication date
1 January 2026
Language
EN