Pd( ii )-catalyzed domino aminopalladation/desymmetrizative ring-opening of diazabicycles: synthesis of indolyl-functionalized cyclopentenylamines

Chemical Communications 2026

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Authors: Haoyuan Lin, Junjie Meng, Yue Zhang, Zhaodong Li
DOI: 10.1039/d6cc00349d
Cited by: 1
References: 35

Abstract

We report herein a robust Pd(II)-catalyzed domino ring-opening coupling of diazabicyclic alkenes with 2-alkynylanilines, enabling efficient access to a diverse library of densely functionalized indolated cyclopentenylamines. This methodology provides a practical and atom-economic route for the construction of structurally complex indole-cyclopentenylamine derivatives, thus expanding the available toolbox for functionalized cyclopentenamines.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Catalytic Alkyne Reactions Catalytic Cross-Coupling Reactions

Publication details

Journal / source
Chemical Communications
Publisher
Royal Society of Chemistry (RSC)
Volume
62
Issue
31
Pages
8046–8050
Publication date
1 January 2026
Language
EN