Switchable N–H vs . C3–H carboxylation of indoles using dual-function reagents

Chemical Communications 2026 Open access

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Authors: Katherine Elizabeth Marris, Jazmine T. Thorne, Daniel Ryder-Mahoney, Ryan A. Bragg, Charles S. Elmore, Gregory J. P. Perry
DOI: 10.1039/d6cc00532b
Cited by: 1
References: 65

Abstract

transfer reaction with carboxylate salts is described. By altering the reaction conditions either N-H or C3-H carboxylation can occur. The reaction is also applicable to the carboxylation of other indole derivatives and amines. The relevance of this procedure is further demonstrated through the preparation and carbon isotope labelling of several biologically relevant carboxylated indoles/amines.

Fields of Study & Subjects

Carbon dioxide utilization in catalysis Catalytic C–H Functionalization Methods CO2 Reduction Techniques and Catalysts

Publication details

Journal / source
Chemical Communications
Publisher
Royal Society of Chemistry (RSC)
Volume
62
Issue
22
Pages
6101–6105
Publication date
1 January 2026
Language
EN