Structural domain plasticity drives Zn( ii ) distribution and buffering in metallothionein-3

Chemical Communications 2026 Open access

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Authors: Manuel David Peris‐Díaz, Eduard H.T.M. Ebberink, Jan Fiala, Albert J. R. Heck, Artur Krężel
DOI: 10.1039/d6cc00567e
Cited by: 0
References: 38

Abstract

-metallothionein-3 species relevant to zinc metabolism. Sequential Zn(II) dissociation engages both the α- and β-domains through a structurally plastic, interdomain mechanism that underpins regulatory zinc buffering at physiological pZn.

Fields of Study & Subjects

Trace Elements in Health Protein Structure and Dynamics Heavy Metal Exposure and Toxicity

Publication details

Journal / source
Chemical Communications
Volume
62
Issue
35
Pages
8942–8946
Publication date
1 January 2026
Language
EN