Silicon rhodamine-based fluorescent probes for monitoring mitochondrial viscosity dynamics during mitophagy

Chemical Communications 2026

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Authors: Zixuan Zhao, Hongling Li, Lijun Li, Zhuo Li, Qi Ai, Xin Wen, Baoxiang Gao
DOI: 10.1039/d6cc00586a
Cited by: 2
References: 36

Abstract

Mitochondrial autophagy (mitophagy) is pivotal for mitochondrial quality control and intracellular homeostasis. However, real-time visualization of mitochondrial inner membrane viscosity - a key biophysical parameter of mitophagy - remains challenging. To address this, a silicon rhodamine (SiR)-based dual-modal imaging probe was developed, enabling reliable real-time monitoring of mitophagic processes and providing novel insights into mitochondrial remodeling during autophagy.

Fields of Study & Subjects

Mitochondrial Function and Pathology Molecular Sensors and Ion Detection Autophagy in Disease and Therapy

Publication details

Journal / source
Chemical Communications
Publisher
Royal Society of Chemistry (RSC)
Volume
62
Issue
31
Pages
7965–7969
Publication date
1 January 2026
Language
EN