Catalytic electron donor–acceptor complex triggered cascade radical trifluoromethylation/cyclization of N -isopentenyl aldehyde hydrazones
Abstract
-isopentenyl aldehyde hydrazones triggered by a catalytic electron donor-acceptor (EDA) complex was developed for the construction of C5-trifluoromethylated tetrahydropyridazines. A catalytic amount of tris(4-bromophenyl)amine was used as the electron donor with trifluoromethyl thianthrenium triflate as the acceptor to generate a trifluoromethyl radical after irradiation. This environmentally benign methodology eliminates the need for a photocatalyst, offering a straightforward and efficient approach to accessing C5-trifluoromethylated tetrahydropyridazines.
Fields of Study & Subjects
Fluorine in Organic Chemistry
Radical Photochemical Reactions
Catalytic C–H Functionalization Methods
Publication details
- Journal / source
- Chemical Communications
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 62
- Issue
- 29
- Pages
- 7539–7543
- Publication date
- 1 January 2026
- Language
- EN