Bioorthogonal tuning of nanosurface opsonisation via click coupling of a complement fusion protein inhibitor

Chemical Communications 2026 Open access

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Authors: Sarah Jacques, Hanmant Gaikwad, Jemma Pillatzke, Seyed Moein Moghimi, Dmitri Simberg
DOI: 10.1039/d6cc00733c
Cited by: 1
References: 37

Abstract

a PEG spacer and copper-free click chemistry overcomes complement opsonisation. Furthermore, CR2-CR1-conjugated nanoworms reduce complement opsonisation of unmodified nanoparticles.

Fields of Study & Subjects

Monoclonal and Polyclonal Antibodies Research Complement system in diseases Biochemical and Structural Characterization

Publication details

Journal / source
Chemical Communications
Publisher
Royal Society of Chemistry (RSC)
Volume
62
Issue
51
Pages
12859–12862
Publication date
1 January 2026
Language
EN