Highly diastereoselective synthesis of borylcyclopropanes by copper-catalyzed borylcyclopropanation of alkenes with enynones

Chemical Communications 2026

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Authors: Fei Lu, Daan Song, Xinhao Sun, Ling Zhi, Xiaoyun Liu, Ximei Zhao, Guanghui Wang
DOI: 10.1039/d6cc00756b
Cited by: 1
References: 78

Abstract

The copper-catalyzed diastereoselective borylcyclopropanation of alkenes with α-furyl boryl copper carbenes generated from BMIDA-terminated enynones allows facile and practical synthesis of various borylcyclopropanes in moderate to excellent yields (up to 98%) with excellent diastereoselectivities (mostly d.r. > 25 : 1) under mild reaction conditions. Moreover, this protocol is applicable for the late-stage functionalization of complex bioactive molecules, which together with large-scale experiments and synthetic transformations of the products demonstrate the synthetic potential of this methodology.

Fields of Study & Subjects

Cyclopropane Reaction Mechanisms Organoboron and organosilicon chemistry Catalytic Alkyne Reactions

Publication details

Journal / source
Chemical Communications
Publisher
Royal Society of Chemistry (RSC)
Volume
62
Issue
36
Pages
9213–9217
Publication date
1 January 2026
Language
EN