A direct route to ynones: Pd-catalyzed Sonogashira carbonylative coupling of ethers with alkynes via C–O cleavage
Abstract
Herein, we report a catalytic strategy that directly utilizes benzylic ethers as coupling partners through a palladium/copper co-catalyzed pathway. The reaction exhibits broad substrate scope, accommodating a wide range of functionalized benzylic alcohols and terminal alkynes, and provides direct access to valuable ynones.
Fields of Study & Subjects
Catalytic Cross-Coupling Reactions
Catalytic C–H Functionalization Methods
Catalytic Alkyne Reactions
Publication details
- Journal / source
- Chemical Communications
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 62
- Issue
- 21
- Pages
- 5960–5964
- Publication date
- 1 January 2026
- Language
- EN