Tunable regioselectivity for C–H alkynylation of weakly coordinating amides that tolerated strongly coordinating heterocycles

Chemical Communications 2026

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Authors: Bifu Liu, Qiaoya Zhang, Jun Zhang, Aidong Huang, Hulin Zhong, Kejun Feng, Yang Gao, Yanping HUO, Q. Chen, Xianwei Li
DOI: 10.1039/d6cc00867d
Cited by: 1
References: 50

Abstract

A weakly coordinating amide-directed C-H alkynylation enables late-stage modification of complex drug and material analogues bearing multiple reactive C-H bonds. This approach achieves divergent regioselectivity in celecoxib and valdecoxib derivatives that contained strongly coordinating heterocycles, by exploiting complementary reactivity between amide substrates, metal catalysts, and haloalkyne coupling partners.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Advanced Synthetic Organic Chemistry Chemical Synthesis and Analysis

Publication details

Journal / source
Chemical Communications
Publisher
Royal Society of Chemistry (RSC)
Volume
62
Issue
23
Pages
6373–6377
Publication date
1 January 2026
Language
EN