Preparation of covalent organic frameworks coated with cell membranes for precise analysis of cancer exosomes

Chemical Communications 2026

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Authors: Minghui Wang, Yue He, Zhenyong Hu, Qiaolin Guo, C.J. Chen, Lai Zhang, Yue Yu (260119), Genxi Li
DOI: 10.1039/d6cc00954a
Cited by: 1
References: 24

Abstract

In this study, we have developed an electrochemical biosensor based on cell membrane-coated covalent organic frameworks for the selective detection of homologous exosomes. The biosensor can achieve a detection limit as low as 27 particles per µL. Moreover, it can effectively differentiate serum samples from patients with triple-negative breast cancer and luminal A breast cancer subtypes.

Fields of Study & Subjects

Covalent Organic Framework Applications Polydiacetylene-based materials and applications Electrochemical sensors and biosensors

Publication details

Journal / source
Chemical Communications
Publisher
Royal Society of Chemistry (RSC)
Volume
62
Issue
24
Pages
6546–6549
Publication date
1 January 2026
Language
EN