Molecular engineering of asymmetric aza-BODIPY dyes for high-performance phototherapy

Chemical Communications 2026

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Authors: Yuting Wang, You Dou, Xiao‐Fang Guan, Panxing Qiu, Wenjun Zhang, Ziyang Hou, Junhua Zhang, Liying Xu, Ci Zhao, Yao Sun, Jun Li
DOI: 10.1039/d6cc01019a
Cited by: 1
References: 38

Abstract

Achieving both anti-fluorescence and anti-ROS quenching effects remains a challenge for conventional small-molecule dyes. In this work, we proposed an "asymmetric hierarchical modulation" strategy for the aza-BODIPY core to address the issues of aggregation-caused fluorescence quenching (ACQ-FL) and aggregation-caused ROS quenching (ACQ-ROS), enabling its high-performance phototherapy. Compound BT-4 exhibited long-wavelength absorption and good anti-fluorescence and anti-ROS quenching abilities. The tumor growth in mouse models was significantly suppressed after treatment with BT-4 plus 808 nm laser irradiation, while maintaining minimal systemic toxicity.

Fields of Study & Subjects

Luminescence and Fluorescent Materials Nanoplatforms for cancer theranostics Carbon and Quantum Dots Applications

Publication details

Journal / source
Chemical Communications
Publisher
Royal Society of Chemistry (RSC)
Volume
62
Issue
42
Pages
10737–10740
Publication date
1 January 2026
Language
EN