HFIP-promoted strain-release rearrangement/ N -functionalization of azabicyclo[1.1.0]butanes with para -quinone methides for the synthesis of azetidines

Chemical Communications 2026

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Authors: Haijian Wu, Manman Sun, Zhiming Wang, Jianguo Yang, Gangguo Zhu
DOI: 10.1039/d6cc01195k
Cited by: 4
References: 50

Abstract

A metal-free methodology for the synthesis of N -alkyl-substituted azetidines through strain-release-driven rearrangement/ N -alkylation of ABBs with p -QMs is reported, in which HFIP plays the key role acting as a dual activator of both ABBs and p -QMs.

Fields of Study & Subjects

N-Heterocyclic Carbenes in Organic and Inorganic Chemistry Catalytic C–H Functionalization Methods Click Chemistry and Applications

Publication details

Journal / source
Chemical Communications
Publisher
Royal Society of Chemistry (RSC)
Volume
62
Issue
39
Pages
9964–9968
Publication date
1 January 2026
Language
EN